Shamar Hoyer, 16, was driving a Mercury SUV on Walnut Grove near Walnut Trace when the accident happened. Police said his vehicle hit a curb, then hit a tree on Walnut Trace.
Hoyer was taken to Regional One in critical condition, but died a few hours later after several surgeries, police said.
He was wearing a seat belt and his airbags deployed, police said.
Family said he was on his way to school.
Surveillance video shows a neighbor running to help after hearing the impact.
"We had several people out here kinda helping along," neighbor Tommy Terry said.
Terry said the wreck is just the latest at an intersection that is proving to be a hazard.
"I've had my mailbox taken down four times," Terry said. "I've had a car go through my yard and through my neighbor's yard."
According to Hoyer's Facebook page, he was a student at Germantown High School. His family has set up a Gofundme account for expenses.
Shamar's aunt said her nephew was an amazing young man.
A Shelby County Schools spokesperson said grief counselors have been supporting students and staff this week at Germantown High School.
"Our Family and Community Engagement team is working with the family and school to help coordinate and support their personal fundraising efforts, which is not uncommon when tragic situations like this involve our students or staff," SCS said.