Xzaveon Nixon was killed in the shooting, District Attorney General Mark Davidson said. Others who were injured have not been identified.
A sign on the door of the club identified it as David's Club Jamaica & Sports Bar. Davidson said he was checking on possible prior complaints about that location.
Officers were called to a bar in the 200 block of Main Street around 2 a.m. and all of the victims were rushed to area hospitals.
"It's a scary thought man. It's scary for the community, because they should have had this place shut down from the past and all. It's been going on for years," Robert Beasley said.
"It's quiet. It's just that sometimes on Friday the clubs open and the Sheriff's Departments comes through to try and make sure it shuts down at a reasonable time, but when you get people that get alcohol in their system, things tend to happen," Delvric Alston said.
So far there's no word on what led to the violent incident.
Lauderdale County has called in the Tennessee Bureau of Investigation to assist in the investigation. So far, no arrests have been made.