According to the Department of Transportation, the vehicle was heading south towards West Memphis around 1:30 a.m. when it overturned and caught on fire near mile marker 12, which is just north of the city of Marion. The driver of the truck was injured and taken to a nearby hospital for treatment.
The truck was carrying roughly 8,000 gallons of ethanol, the Marion Fire Department said.
The fire was quickly contained but officials had to call in hazmat crews for cleanup.
Officials shut down the interstate from mile marker 10 to mile marker 14.