Police said a black Infiniti was driving on East Holmes Road near Cresser Street around 2:20 p.m. when people in two other cars spotted the Infiniti and opened fire on it.
One of the victims is in critical condition while another is in non-critical condition, police said.
The Infiniti had two flat front tires and visible damage to the windshield. People in the area say they could hear the gunshots up to half a mile away.
"It went on for, like, maybe few times, then it started back," said Larry Ballard.
For several hours, police roped off two blocks of East Holmes and detoured traffic. Detectives both uniformed and undercover combed the area for evidence.
"It’s too early to tell exactly what happened and what this is about," said Col. Mickey Williams with the Memphis Police Department.
Williams wouldn't say if the victims took part in the shooting or if police recovered any weapons from their vehicle, but those details matter little to the people who live and work in the area forced to walk up to yet another shooting scene.
“People just got to realize, you know, life is valuable, you know. Just can’t go around just shooting people," said Cleo Whittier.
"Get you some dog tags and go over there and fight for something instead of fighting for nothing," said Carl Johnson.
Police say they're fighting their own battle working to bring the people responsible for this to justice.
"We wish they would stop but we’re gonna catch them eventually and hopefully recover the guns and get them off the street," Williams said.
No arrests had been made Friday night. Police said the suspect vehicle is believed to be a yellow Chevy Camaro with a black stripe and Mississippi tags.