It happened in the 5900 block of Hickory Leaf Cove just after 11 p.m. Sunday.
The Memphis Fire Department confirmed that one adult was taken to the Regional Medical Center and one juvenile was taken to Le Bonheur Children's Hospital. The man later died from his injuries.
Police said marked off 88 bullet holes in the house, which was occupied by at least five people at the time. Bullet holes start at the garage and go all the way across the house.
"This is not the first time," a neighbor said. "So, I just thought they were doing the same thing. I had no idea someone was shot."
The suspects were reportedly occupying a dark-colored vehicle. It's unknown if the suspects and the victims were known to each other.
Anyone with information should call Crime Stoppers at (901) 528-CASH.