The home in the 600 block of North Dunlap, north of Jackson, was engulfed in flames by about 8 p.m.
Lt. Wayne Cooke with Memphis Fire Department said a family was at home inside the house when the fire started. One of those people was a disabled female.
A civilian helped that person out of the house, Cooke said.
No one was injured, he said.
The home was extensively damaged. Cooke said a cause had not been determined.