Negotiators were in the 900 block of Emmie, in the Rozelle-Annesdale area near McLean and Lamar.
Deputies were serving an arrest warrant for murder with US Marshals shortly after 2 p.m.
The sheriff's office said one person was barricaded inside a home, and several nearby homes were evacuated.
A suspect was arrested shortly before 6:30, but SCSO said it was on an unrelated warrant.
The search for the murder suspect continues.
SCSO identified him as Cadarius Head, 24. They asked anyone with information on Head to contact police immediately.